Holoprosencephaly (HPE) is a developmental defect of the embryonic forebrain and midface. It is due to the non-cleavage of the embryonic forebrain into two cerebral hemispheres and the incomplete development of the paramedian structures. The overall prevalence is 1. https://www.diegojavierfares.com/amazing-price-Rubbermaid-8-Gallon-Plastic-Home-Office-Wastebasket-Trash-Can-with-Liner-Lock-p12316-big-deal/