Here, we present that conolidine, a natural analgesic alkaloid used in common Chinese medication, targets ACKR3, therefore delivering supplemental evidence of a correlation involving ACKR3 and discomfort modulation and opening alternative therapeutic avenues with the remedy of Long-term suffering. The 1st asymmetric full synthesis of conolidine was created by https://bullj711epy1.wikidirective.com/user