, ritonavir) or discontinuation of a cytochrome P450 3A4 inducer including rifampin, carbamazepine, and phenytoin, may perhaps cause an increase in codeine plasma concentrations with subsequently greater metabolism by cytochrome P450 2D6, causing larger morphine levels, which could maximize or extend adverse reactions and may trigger probably lethal respiratory melancholy. https://sethbedaw.suomiblog.com/5-essential-elements-for-akorn-codeine-47935719