If a parent from the proband is understood to contain the pathogenic variant discovered within the proband, the risk for the sibs of inheriting the pathogenic variant is 50%. As a result of diminished penetrance, sibs who inherit the pathogenic variant may or may not create aHUS (see Penetrance). In https://air-handling-unit-ahu-hir60482.blazingblog.com/31907201/the-basic-principles-of-air-handling-unit-ahu-hire