1 obstacle of single go TFF is design constraints are more significant than in multi-pass batch processes. The Sanofi staff found that in place of fixed TMP Handle, SP-TFF involves genuine-time modulation on the TMP, which happens to be difficult to obtain with common technologies. Accordingly, the Sanofi group https://paxtonpdosi.blogdon.net/detailed-notes-on-tff-passing-strategy-39598149